"Adult"

Abnormal venous function in patients with homozygous sickle cell (SS) disease and chronic leg ulcers.
Chronic leg ulceration is a major cause of morbidity in homozygous sickle cell (SS) disease in Jamaica. These ulcers have features in …
J. S. Mohan, J. E. Vigilance, J. M. Marshall, I. R. Hambleton, H. L. Reid, G. R. Serjeant
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Psychological distress among younger siblings of patients with homozygous sickle cell disease in the Jamaican cohort study.
The presence of a chronically ill family member may adversely affect the psychological health of siblings. This study used the General …
K. Foster-Williams, I. R. Hambleton, C. Hilton, G. R. Serjeant
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Gallstones in sickle cell disease: observations from The Jamaican Cohort study.
The prevalence, incidence, risk factors, clinical associations, and morbidity of gallstones were studied in 311 patients with …
T. M. Walker, I. R. Hambleton, G. R. Serjeant
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Recurrent infections in homozygous sickle cell disease.
The characteristics of 214 episodes of invasive bacterial infection among 176 patients with homozygous sickle cell (SS) disease were …
S. A. Magnus, I. R. Hambleton, F. Moosdeen, G. R. Serjeant
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Postsplenectomy course in homozygous sickle cell disease.
OBJECTIVE: To determine whether children with homozygous sickle cell (SS) disease and splenectomy are at greater risk of death, …
J. G. Wright, I. R. Hambleton, P. W. Thomas, N. D. Duncan, S. Venugopal, G. R. Serjeant
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Day-care management of sickle cell painful crisis in Jamaica: a model applicable elsewhere?
In the U.K. and the U.S.A., painful crises account for 80-90% of sickle-related hospital admissions, with average durations of 5-11 d. …
M. A. Ware, I. Hambleton, I. Ochaya, G. R. Serjeant
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Comparison of responses evoked by mild indirect cooling and by sound in the forearm vasculature in patients with homozygous sickle cell disease and in normal subjects.
In normal individuals, novel or noxious stimuli commonly evoke the pattern of the alerting or defence response which includes cutaneous …
J. S. Mohan, J. M. Marshall, H. L. Reid, P. W. Thomas, I. Hambleton, G. R. Serjeant
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Peripheral vascular response to mild indirect cooling in patients with homozygous sickle cell (SS) disease and the frequency of painful crisis.
  1. In homozygous sickle cell (SS) disease, skin cooling is a common precipitating factor of the painful crisis which is associated with …
J. Mohan, J. M. Marshall, H. L. Reid, P. W. Thomas, I. Hambleton, G. R. Serjeant
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Population-based study of risk of venous thromboembolism associated with various oral contraceptives.
BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in …
R. D. Farmer, R. A. Lawrenson, C. R. Thompson, J. G. Kennedy, I. R. Hambleton
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Oral contraceptive switching patterns in the United Kingdom: an important potential confounding variable in studies of venous thromboembolism.
OBJECTIVE: To investigate whether patients changing from their current oral contraceptive (OC) are preferentially switched to …
R. D. Farmer, R. A. Lawrenson, I. R. Hambleton
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