"Homozygote"

Causes of death and early life determinants of survival in homozygous sickle cell disease: The Jamaican cohort study from birth.
Globally, the majority of persons born with sickle cell disease do not have access to hydroxyurea or more expensive interventions. The …
Graham R. Serjeant, Nicki Chin, Monika R. Asnani, Beryl E. Serjeant, Karlene P. Mason, Ian R. Hambleton, Jennifer M. Knight-Madden
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Clinical findings associated with homozygous sickle cell disease in the Barbadian population--do we need a national SCD registry?
BACKGROUND: Comprehensive care in homozygous sickle cell disease (HbSS) entails universal neonatal screening and subsequent monitoring …
Kim R. Quimby, Stephen Moe, Ian Sealy, Christopher Nicholls, Ian R. Hambleton, R. Clive Landis
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Homozygous sickle cell disease in Uganda and Jamaica a comparison of Bantu and Benin haplotypes.
OBJECTIVE: To compare the haematological and clinical features of homozygous sickle cell (SS) disease in Bantu and Benin haplotypes in …
C. Ndugwa, D. Higgs, C. Fisher, I. Hambleton, K. Mason, B. E. Serjeant, G. R. Serjeant
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The changing face of homozygous sickle cell disease: 102 patients over 60 years.
Earlier reports on homozygous sickle cell (SS) disease have been biased by severely affected cases. The Jamaican clinic which seeks to …
G. R. Serjeant, B. E. Serjeant, K. P. Mason, I. R. Hambleton, C. Fisher, D. R. Higgs
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Albuminuria and renal function in homozygous sickle cell disease: observations from a cohort study.
BACKGROUND: The glomerular filtration rate (GFR) in homozygous sickle cell (SS) disease is supranormal in childhood but falls steeply …
Joanne Thompson, Marvin Reid, Ian Hambleton, Graham R. Serjeant
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Elderly survivors with homozygous sickle cell disease.
Graham R. Serjeant, Douglas R. Higgs, Ian R. Hambleton
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Outcome of pregnancy in homozygous sickle cell disease.
OBJECTIVE: Previous reports on pregnancy in homozygous sickle cell (SS) disease are biased by hospital-based, more severely affected …
Graham R. Serjeant, Luana Look Loy, Mark Crowther, Ian R. Hambleton, Minerva Thame
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Identifying homozygous sickle cell disease when neonatal screening is not available: a clinic-based observational study.
OBJECTIVES: Life-threatening clinical complications can occur in the first years of life in people with homozygous sickle cell disease. …
I. R. Hambleton, K. J. J. Wierenga
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Psychological distress and coping in sickle cell disease: comparison of British and Jamaican attitudes.
OBJECTIVE: To investigate possible differences in coping mechanisms in the painful crisis between Jamaican and London patients with …
V. J. Thomas, I. Hambleton, G. Serjeant
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Survival estimates for patients with homozygous sickle-cell disease in Jamaica: a clinic-based population study.
BACKGROUND: Information about life expectancy of patients with homozygous sickle-cell disease is needed for research and patient …
K. J. Wierenga, I. R. Hambleton, N. A. Lewis
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