"Humans"

A comparison of outcome for stroke patients in Barbados and South London.

BACKGROUND AND AIMS: Little is known about the poststroke outcome in Caribbean populations. We investigated differences in the …

Nigel C. Smeeton, David O. C. Corbin, Anselm J. M. Hennis, Ian R. Hambleton, Angela M. C. Rose, Henry S. Fraser, Peter U. Heuschmann, Charles D. A. Wolfe

A preliminary examination of the effects of genetic variants of redox enzymes on susceptibility to oedematous malnutrition and on percentage cytotoxicity in response to oxidative stress in vitro.

BACKGROUND: The causes of oedematous vs non-oedematous childhood malnutrition (OM vs NOM) remain elusive. It is possible that inherited …

K. G. Marshall, K. Swaby, K. Hamilton, S. Howell, R. C. Landis, I. R. Hambleton, M. Reid, H. Fletcher, T. Forrester, C. A. McKenzie

Hb S-β-thalassemia: molecular, hematological and clinical comparisons.

Clinical and hematological features are presented for 261 patients with identified β-thalassemia (β-thal) mutations. Mutations causing …

Graham R. Serjeant, Beryl E. Serjeant, Raphael A. Fraser, Ian R. Hambleton, Douglas R. Higgs, Andreas E. Kulozik, Alan Donaldson

Pattern of pregnancy weight gain in homozygous sickle cell disease and effect on birth size.

OBJECTIVE: To assess pregnancy weight gain and newborn anthropometry in mothers with homozygous sickle cell (SS) disease and normal …

M. Thame, J. Lewis, I. Hambleton, H. Trotman, G. Serjeant

Are women who work in bars, guesthouses and similar facilities a suitable study population for vaginal microbicide trials in Africa?

BACKGROUND: A feasibility study was conducted to investigate whether an occupational at-risk cohort of women in Mwanza, Tanzania are a …

Andrew Vallely, Ian R. Hambleton, Stella Kasindi, Louise Knight, Suzanna C. Francis, Tobias Chirwa, Dean Everett, Charles Shagi, Claire Cook, Celia Barberousse, Deborah Watson-Jones, John Changalucha, David Ross, Richard J. Hayes

Association of schistosomiasis with false-positive HIV test results in an African adolescent population.

This study was designed to investigate the factors associated with the high rate of false-positive test results observed with the …

Dean B. Everett, Kathy J. Baisely, Ruth McNerney, Ian Hambleton, Tobias Chirwa, David A. Ross, John Changalucha, Deborah Watson-Jones, Helena Helmby, David W. Dunne, David Mabey, Richard J. Hayes

The changing face of homozygous sickle cell disease: 102 patients over 60 years.

Earlier reports on homozygous sickle cell (SS) disease have been biased by severely affected cases. The Jamaican clinic which seeks to …

G. R. Serjeant, B. E. Serjeant, K. P. Mason, I. R. Hambleton, C. Fisher, D. R. Higgs

Anaesthetic morbidity at the University Hospital of the West Indies.

OBJECTIVE: There is little information on adverse anaesthetic outcomes from the Caribbean. The aim of this study was to investigate the …

I. A. Tennant, R. Augier, A. Crawford-Sykes, I. R. Hambleton, M. Tha, H. Harding

Measurement and predictors of adherence in a trial of HSV suppressive therapy in Tanzania.

This study estimates adherence and identifies predictors of good adherence among 1305 Tanzanian women participating in a randomised, …

Deborah Watson-Jones, Kathy Baisley, Mary Rusizoka, Clare Tanton, Kokugonza Mugeye, Helen A. Weiss, John Changalucha, Tim Clayton, Ian Hambleton, David A. Ross, Richard J. Hayes

Rate of change of sickle allele frequency may be influenced by total fertility rate: a sesquicentenary reflection on human micro-evolution.

Colin A. McKenzie, Neil A. Hanchard, Rosalind Harding, Ian Hambleton, Bernadette Modell