"Neonatal Screening"

Newborn screening for abnormal haemoglobins in Jamaica: Practical issues in an island programme.
OBJECTIVE: To report the diagnostic challenges of newborn screening for abnormal haemoglobins. SETTING: Cord blood samples from 13 …
Serjeant, Graham R, Serjeant, Beryl E, Mason, Karlene P, Gibson, Felicea, Gardner, Ruth-Ann, Warren, Lansford, Hambleton, Ian R, Thein, Swee L, Happich, Margit
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A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin.
The gene for hereditary persistence of fetal hemoglobin (HPFH) in the Caribbean is much more common than previously estimated. To avoid …
Graham R. Serjeant, Beryl E. Serjeant, Ian R. Hambleton, Matthew Oakley, Swee Lay Thein, Barnaby Clark
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Hb S-β-thalassemia: molecular, hematological and clinical comparisons.
Clinical and hematological features are presented for 261 patients with identified β-thalassemia (β-thal) mutations. Mutations causing …
Graham R. Serjeant, Beryl E. Serjeant, Raphael A. Fraser, Ian R. Hambleton, Douglas R. Higgs, Andreas E. Kulozik, Alan Donaldson
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Predicted declines in sickle allele frequency in Jamaica using empirical data.
The high frequency of the sickle allele in some parts of Africa is understood to be a consequence of high malarial endemicity. One …
N. A. Hanchard, I. Hambleton, R. M. Harding, C. A. McKenzie
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The frequency of the sickle allele in Jamaica has not declined over the last 22 years.
The ‘malaria hypothesis’ predicts that the frequency of the sickle allele, which is high in malaria-endemic African …
N. A. Hanchard, I. Hambleton, R. M. Harding, C. A. McKenzie
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Newborn screening for sickle cell disease in Brazil: the Campinas experience.
Newborn screening for sickle cell disease commenced in 1992 in Sao Paulo State and by the end of 2000, the programme covered 78 …
S. Brandelise, V. Pinheiro, C. S. Gabetta, I. Hambleton, B. Serjeant, G. Serjeant
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