Ian Hambleton
Ian Hambleton
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"Neonatal Screening"
A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin.
The gene for hereditary persistence of fetal hemoglobin (HPFH) in the Caribbean is much more common than previously estimated. To avoid …
Graham R. Serjeant
,
Beryl E. Serjeant
,
Ian R. Hambleton
,
Matthew Oakley
,
Swee Lay Thein
,
Barnaby Clark
Cite
DOI
Clinical findings associated with homozygous sickle cell disease in the Barbadian population--do we need a national SCD registry?
BACKGROUND: Comprehensive care in homozygous sickle cell disease (HbSS) entails universal neonatal screening and subsequent monitoring …
Kim R. Quimby
,
Stephen Moe
,
Ian Sealy
,
Christopher Nicholls
,
Ian R. Hambleton
,
R. Clive Landis
Cite
DOI
Hb S-β-thalassemia: molecular, hematological and clinical comparisons.
Clinical and hematological features are presented for 261 patients with identified β-thalassemia (β-thal) mutations. Mutations causing …
Graham R. Serjeant
,
Beryl E. Serjeant
,
Raphael A. Fraser
,
Ian R. Hambleton
,
Douglas R. Higgs
,
Andreas E. Kulozik
,
Alan Donaldson
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DOI
Predicted declines in sickle allele frequency in Jamaica using empirical data.
The high frequency of the sickle allele in some parts of Africa is understood to be a consequence of high malarial endemicity. One …
N. A. Hanchard
,
I. Hambleton
,
R. M. Harding
,
C. A. McKenzie
Cite
DOI
The frequency of the sickle allele in Jamaica has not declined over the last 22 years.
The ‘malaria hypothesis’ predicts that the frequency of the sickle allele, which is high in malaria-endemic African …
N. A. Hanchard
,
I. Hambleton
,
R. M. Harding
,
C. A. McKenzie
Cite
DOI
Newborn screening for sickle cell disease in Brazil: the Campinas experience.
Newborn screening for sickle cell disease commenced in 1992 in Sao Paulo State and by the end of 2000, the programme covered 78 …
S. Brandelise
,
V. Pinheiro
,
C. S. Gabetta
,
I. Hambleton
,
B. Serjeant
,
G. Serjeant
Cite
DOI
Identifying homozygous sickle cell disease when neonatal screening is not available: a clinic-based observational study.
OBJECTIVES: Life-threatening clinical complications can occur in the first years of life in people with homozygous sickle cell disease. …
I. R. Hambleton
,
K. J. J. Wierenga
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DOI
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