"Anemia"

Homozygous sickle cell disease in Uganda and Jamaica a comparison of Bantu and Benin haplotypes.
OBJECTIVE: To compare the haematological and clinical features of homozygous sickle cell (SS) disease in Bantu and Benin haplotypes in …
C. Ndugwa, D. Higgs, C. Fisher, I. Hambleton, K. Mason, B. E. Serjeant, G. R. Serjeant
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Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease.
BACKGROUND: Bronchodilators are used to treat bronchial hyper-responsiveness in asthma. Bronchial hyper-responsiveness may be a …
Jennifer M. Knight-Madden, Ian R. Hambleton
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Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease.
BACKGROUND: Sickle cell disease can cause severe vaso-occlusive crises and dysfunction of most organ systems. The two most common …
Gavin Cho, Ian R. Hambleton
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Hb S-β-thalassemia: molecular, hematological and clinical comparisons.
Clinical and hematological features are presented for 261 patients with identified β-thalassemia (β-thal) mutations. Mutations causing …
Graham R. Serjeant, Beryl E. Serjeant, Raphael A. Fraser, Ian R. Hambleton, Douglas R. Higgs, Andreas E. Kulozik, Alan Donaldson
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Pattern of pregnancy weight gain in homozygous sickle cell disease and effect on birth size.
OBJECTIVE: To assess pregnancy weight gain and newborn anthropometry in mothers with homozygous sickle cell (SS) disease and normal …
M. Thame, J. Lewis, I. Hambleton, H. Trotman, G. Serjeant
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The changing face of homozygous sickle cell disease: 102 patients over 60 years.
Earlier reports on homozygous sickle cell (SS) disease have been biased by severely affected cases. The Jamaican clinic which seeks to …
G. R. Serjeant, B. E. Serjeant, K. P. Mason, I. R. Hambleton, C. Fisher, D. R. Higgs
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Rate of change of sickle allele frequency may be influenced by total fertility rate: a sesquicentenary reflection on human micro-evolution.
Colin A. McKenzie, Neil A. Hanchard, Rosalind Harding, Ian Hambleton, Bernadette Modell
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Retained placenta in homozygous sickle cell disease.
OBJECTIVE: To document an increased prevalence of retained placenta in mothers with homozygous sickle cell disease. METHODS: A …
Donnette Simms-Stewart, Minerva Thame, Aleith Hemans-Keen, Ian Hambleton, Graham R. Serjeant
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Auto-adjusting positive airway pressure in children with sickle cell anemia: results of a phase I randomized controlled trial.
Low nocturnal oxygen saturation (SpO(2)) is implicated in complications of Sickle Cell Anemia (SCA). Twenty-four children with SCA were …
Melanie J. Marshall, Romola S. Bucks, Alexandra M. Hogan, Ian R. Hambleton, Susan E. Height, Moira C. Dick, Fenella J. Kirkham, David C. Rees
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The mechanisms of low birth weight in infants of mothers with homozygous sickle cell disease.
OBJECTIVE: A low mean birth weight is a constant finding in pregnancies of women with homozygous sickle cell disease. The factors …
Minerva Thame, Jillian Lewis, Helen Trotman, Ian Hambleton, Graham Serjeant
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